Effects of β2-glycoprotein I and monoclonal anticardiolipin antibodies in platelet interaction with subendothelium under flow conditions
نویسندگان
چکیده
منابع مشابه
Optimization of Unnicked β2-Glycoprotein I and High Avidity Anti-β2-Glycoprotein I Antibodies Isolation
Patient biological material for isolation of β2-glycoprotein I (β2GPI) and high avidity IgG anti-β2-glycoprotein I antibodies (HAv anti-β2GPI) dictates its full utilization. The aim of our study was to evaluate/improve procedures for isolation of unnicked β2GPI and HAv aβ2GPI to gain unmodified proteins in higher yields/purity. Isolation of β2GPI from plasma was a stepwise procedure combining n...
متن کاملAnticardiolipin and anti-beta2-glycoprotein I antibodies in Behcet's disease.
To investigate prevalence of anticardiolipin antibodies (aCL) in patients with Behcet's disease (BD) and to determine whether they are related to anti-beta2-glycoprotein I antibodies (aGPI), we measured aCL and aGPI in 47 patients of BD and 14 patients of systemic lupus erythematosus (SLE). The levels of aCL and aGPI were determined by conventional enzyme immunoassay for both IgG and IgM classe...
متن کاملAssociation of anticardiolipin, antiphosphatidylserine, anti-β2 glycoprotein I, and antiphosphatidylcholine autoantibodies with canine immune thrombocytopenia
BACKGROUND In humans, the presence of antiphospholipid antibodies (aPL) is frequently found in immune thrombocytopenia. The present study investigated whether aPL and any aPL subtypes are associated with canine thrombocytopenia, in particular, immune-mediated thrombocytopenia (immune thrombocytopenia) that usually manifests with severe thrombocytopenia. RESULTS Sera were collected from 64 out...
متن کاملInhibition of Apc Anticoagulant Activity on Oxidized Phospholipid by Anti-β2-glycoprotein I Monoclonal Antibodies
This research was supported by a Specialized Center on Thrombosis grant awarded by the National Heart, Lung and Blood Institute of the National Institutes of Health (grant no. P50 HL54502; NLE). CTE is an investigator of the Howard Hughes Medical Institute and holds the Lloyd Noble Chair in Cardiovascular Research at the Oklahoma Medical Research Foundation. *O. Safa current address: Biomerieux...
متن کاملEffects of flow pulsatility on platelet adhesion to subendothelium.
Platelet adhesion in the annular perfusion system developed by Baumgartner was studied under pulsatile, oscillatory, or steady flow conditions. To investigate in what way pulsatile flow affects platelet adhesion, we developed a flow system that produces a sinusoidal laminar flow superimposed on a constant component in the annular perfusion chamber. Frequencies and amplitudes of this sinusoidal ...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 2002
ISSN: 0004-3591
DOI: 10.1002/art.10634